_____ _____ ____（在16世纪40年代）,he got serious disease.
问题描述：
_____ _____ ____（在16世纪40年代）,he got serious disease.
The _____ （形式、情形）is becoming worse and worse now.
There are a lot of _____（松散的）sweets on the ground.
答
In the 1540s.
situation
loose