He asks her ,what is wrong with you?合并为一句

He asks her what is wrong with her.

正确的应该是:he asks her what was wrong.
可以查阅词典!

i can not believe that you guys above are totally wrong
正确地翻译应该是
He asks her what is wrong with

what's wrong with you he asks

He asks her(that) what is(was)[根据情况来定] wrong with her

He asks her what's wrong with you.

He asks her （that）what wrong is with her
从句是用陈述句态.
that可加可不加 但习惯用法是加.使得句式明朗些..

He asks her ,what is wrong with you?
后边这句话是一种特殊情况,作宾语从句时,时态可以变,语序一定要保持不变.但鉴于主句为一般时态,
所以,正确做法应该是：He asks her what is wrong with her.

He asks her what's wrong with her.
what在这里做主语

He asks what wrong with her.