and和with有什么区别?他们又怎么用?

and 连接并列的名词、代词或数词and前后时态要相同.
with 有, 以, 用, 同...,由于, 和...一致, 赞成, 关于, 就.(与副词连用，表示祈使)

and一般是加某物，但是with是加某人

and:
1. used to join two words or expressions
和、及、又、与、同
ex: my mother and father like swimming very much
He was cold and hungry.
2. used to show that two things happen at the same time or almost at the same time
用于表示两件事同时发生或者几乎同时发生
ex: I woke up and got out of bed.
with:
usd to show that people do something together表示人们一起做某事
ex: he never plays with his brother.

and和with虽然都有"和"的意思,但前者是连词,后者是介词.

你一定在为“和.”的用法而困惑呵呵
意义上,两个是一样的
但是语法上,AND连接的词属于并列成分,
A and B中,A B是平行的
而WITH和后面的词构成“介词+宾语”的结构
A with B中,A B是不平行的,A是主要成分,with B则是个附属成分

同意楼上harryzb888.
and是句子的连词,顾名思义是连接句子或名词或短语,用法很灵活
with是一个介词,就是后面加名词或短语,用法也很灵活.

看看用法就知道了。
and
1. 和,及,与,同;又
They sang and danced all night.
他们通宵唱歌跳舞。
My mother and father have never agreed on this matter.
我父母在这件事情上从未意见一致过。
2. 然后
She went to the United States in 1960 and has lived there ever since.
她于一九六○年去了美国,此后就一直住在那里。
3. 而且
You must stop, and at once, this sort of behavior.
你必须停止此类行为,而且必须立即停止。
4. 就;所以,因此
Go straight on and you'll see a church.
一直走下去你便可以看到一座教堂。
5. 而,但是
Vegetable oil is digestible and mineral oil is not.
植物油易消化而矿物油则不行。
with
1. 与...一起,偕同,和...
She lives with her son.
她和儿子住在一起。
2. 带着...;有...的
The girl with long hair is my classmate.
长头发的女孩是我同学。
3. 以(手段、材料),用(工具)
My American friend is learning to eat with chopsticks.
我的一位美国朋友在学着用筷子吃饭。
4. 符合,一致
5. 在...一边,赞成
We are with you there.
在那一点上我们站在你这一边。
6. 跟...,反对
The Allied Forces fought with Germany.
盟军跟德国交战。
7. 顺...方向,跟...一起
8. 加上,包括...在内
His bank savings, with his wife's jewels, amount to three million dollars.
他的银行存款加上他太太的首饰合计达三百万元。
9. 随着,对应
An independent man, Peter never goes with the tide.
彼得是个有主见的人,从不随大流。
10. 在...身边,在...身上
He had a gun with him.
他带了枪。
I have no money with me.
我身边没有钱。
11. 与...(相比)
12. 跟...(分手)
I parted with my brother in Paris.
我跟我兄弟在巴黎分手。
13. 尽管有
With all the setbacks, he did not lose heart.
尽管遭受种种挫折,他没有丧失信心。
14. 由于,因为
They were wild with joy.
他们欣喜若狂。
15. (与副词连用构成祈使句,表示强烈的愿望)
Down with fascism!
打倒法西斯主义!