α-磷酸甘油穿梭相对苹果酸-天冬氨酸穿梭有什么好处
α-磷酸甘油穿梭相对苹果酸-天冬氨酸穿梭有什么好处
前者生成1.5ATP后者2.5ATP,但都是将2H带入线粒体内,为什么会有低效率的穿梭存在呢?
1. In humans, the glycerol phosphate shuttle is primarily found in brown adipose tissue, as the conversion is less efficient, thus generating heat, which is one of the main purposes of brown fat. It is primarily found in babies, though it is present in small amounts in adults around the kidneys and on the back of our necks
2. The glycerol 3-phosphate shuttle is used to rapidly regenerate NAD+ in brain and skeletal muscle cells of mammals.
3.The use of FAD enables electrons from cytosolic NADH to be transported into mitochondria against an NADH concentration gradient. The price of this transport is one molecule of ATP per two electrons. This glycerol 3-phosphate shuttle is especially prominent in muscle and enables it to sustain a very high rate of oxidative phosphorylation你这个等于没有回答。我知道一个在脑部,一个在肌肉。但是2个H带来的1。5ATP并不是所谓的"a very high rate of oxidative phosphorylation”而是“相对低效率的”你肿么不明白呢。。。我再给你解释下好了,这里总结三条好处在某些特殊的tissue里面,损耗的ATP量可以用来做其他用,比如,产生热glycerol-3-phosphate shuttle 恢复细胞质内NAD+的速率更高,也就是说,把能量转移到线粒体内更快当线粒体内NADH浓度高的时候,另一个shuttle的作用就会受抑制,所以glycerol-3-phosphate shuttle 的存在可以不受线粒体内部NADH 浓度的影响这是我在一篇paper里面查的