be careful of/about/with/in的区别be careful 后面可以接of/about/with/in/to do 他们直接有什么区别尤其是前3个,最好详细一点,有例句和用法.

be careful of …
注意,小心......后接名词,动名词或从句.
Please be careful of your spelling.
Be careful of what they have said.
be careful with…
小心……
[句型解析]
嘱咐别人小心做事, 我们可以用上“Be careful with...”，“with”后接名词或动名词。也可以说“Be careful (not) to do...”或“Be careful that you don’t...”。
[实例]
1. Be careful with the wet paint.
小心,油漆未干。
2. Be careful that you don’t catch a cold. Put on more clothes before you go out.
小心别感冒了。出门之前多穿点衣服。
3. Be careful not to spill the milk.
小心别把牛奶溅出来了
1.be careful + about/of+ 名词 注意...的
eg.She is careful about/of her food.
=She is careful about/of what she eats.
她很注意饮食。（后面界wh- 从句时，多省略介词）
Be careful in:
prep. 注意
Be careful in dealing with such people.
与这种人打交道要小心谨慎。
Be careful in可+ 动名词的短语, 也可 + 名词
可以参考下这里.

其实也没多大的区别 平时可以互换
be careful of=be careful about 小心 对什么谨慎 注意 表示注意自己健康等的方面 注意做到什么
be careful with=be careful in 嘱咐别人小心做事 是要注意别让某东西毁坏 或者让某物或某事伤害到自己
但是Be careful of强调对...认真,细心,小心（比较褒义）
例句：You are very careful of your work.你对你的工作很谨慎/认真
Be careful (not) to do...小心地做某事