it takes me about twenty minutes to ride to school,此句中的to ride to school,能不能换成to by bike to school,

It takes me about twenty minutes to school by bike.

不能。
原因是by bike 是介词结构，不能当动词用。动词结构的应该是 take bike to school。不过ride在这里已经本身包含了“汽车”的意思了，没必要再指明说bike。
如果真想用bike表达“骑自行车上学”，应该这样说：
It takes me about twenty minute to get to school by bicycle/bike.

不能.
朋友,你说的是中文语序,不能按中文的语序来进行翻译或者写作.
by后面跟交通工具,一般都要后置,这是英语中的规范.你可以改为：it takes me about twenty minutes to (go to 可以省略)school by bike,
不懂追问.

可以换成to school by bike，英语一般不能说to by bike to school，这是错误的。